サイトリの技術及び機器は、前臨床研究及び臨床研究で評価が行われており、査読を受けた論文が掲載されています。
| 前十字靱帯修復： | ・Cugat R et al. Biological Augmentation of ACL Reconstruction [abstract]. In: The Orthobiologic Institute (TOBI) 7th Annual PRP & Regenerative Medicine Symposium with Cadaver Lab.; 2016 Jun 10 – 12; Las Vegas, NV. Healthy Aging Research; 2017. Abstract nr 2. |
| 急性腎障害： | ・Feng Z et al. Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia-reperfusion-induced acute kidney injury. Nephrol Dial Transplant. 2010 Dec;25(12):3874-84. doi: 10.1093/ndt/gfq603. |
| 毛髪再生： | ・Perez-Meza D et al. Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness. Stem Cells Cloning. 2017 Jul 6;10:1-10. doi: 10.2147/SCCAA.S131431. eCollection 2017. |
| 骨再生： | ・Prins H et al. Bone Regeneration Using the Freshly Isolated Autologous Stromal Vascular Fraction of Adipose Tissue in Combination With Calcium Phosphate Ceramics. Stem Cells Transl Med. 2016 Oct;5(10):1362-1374. ・Saxer F et al. Implantation of Stromal Vascular Fraction Progenitors at Bone Fracture Sites: From a Rat Model to a First-in-Man Study. Stem Cells. 2016 Dec;34(12):2956-2966. doi: 10.1002/stem.2478. ・Lendeckel S et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg. 2004 Dec;32(6):370-3. |
| 乳房再建・豊胸： | ・Calabrese C et al. Breast reconstruction after nipple/areola-sparing mastectomy using cell-enhanced fat grafting. Ecancermedicalscience. 2009;3:116. doi: 10.3332/ecancer.2009.116. ・Domenis R et al. Adipose tissue derived stem cells: in vitro and in vivo analysis of a standard and three commercially available cell-assisted lipotransfer techniques. Stem Cell Res Ther. 2015 Jan 5;6:2. doi: 10.1186/scrt536. ・Gentile P et al. A comparative translational study: the combined use of enhanced stromal vascular fraction and platelet-rich plasma improves fat grafting maintenance in breast reconstruction. Stem Cells Transl Med. 2012 Apr;1(4):341-51. doi: 10.5966/sctm.2011-0065. ・Gentile P et al. Breast Reconstruction with Enhanced Stromal Vascular Fraction Fat Grafting: What Is the Best Method? Plast Reconstr Surg Glob Open. 2015 Jul 8;3(6):e406. doi: 10.1097/GOX.0000000000000285. eCollection 2015 Jun. ・Ito S et al. Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer. Surg Today. 2017 Dec;47(12):1500-1511. doi: 10.1007/s00595-017-1544-4. ・Kamakura T et al. Autologous cell-enriched fat grafting for breast augmentation. Aesthetic Plast Surg. 2011 Dec;35(6):1022-30. doi: 10.1007/s00266-011-9727-7. ・Pérez-Cano R et al. Prospective trial of adipose-derived regenerative cell (ADRCs)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol. 2012 May;38(5):382-9. doi: 10.1016/j.ejso.2012.02.178. ・Sugimachi K et al. “Novel breast reconstruction procedure- Attempts of breast regeneration using stem cells after breast cancer mastectomy.” Japan Journal of Cosmetic Surgery, 30(3); 151-160; 2008. ・Tiryaki T et al. Staged stem cell-enriched tissue (SET) injections for soft tissue augmentation in hostile recipient areas: a preliminary report. Aesthetic Plast Surg. 2011 Dec;35(6):965-71. doi: 10.1007/s00266-011-9716-x. ・Tsekouras A et al. Adipose-derived stem cells for breast reconstruction after breast surgery – preliminary results. Case Reports Plast Surg Hand Surg. 2017 Apr 19;4(1):35-41. doi: 10.1080/23320885.2017.1316201. eCollection 2017. |
| 熱傷： | ・Arkoulis N et al. Stem cell enriched dermal substitutes for the treatment of late burn contractures in patients with major burns. Burns. 2018 May;44(3):724-726. doi: 10.1016/j.burns.2017.09.026. ・Foubert P et al. Preclinical assessment of safety and efficacy of intravenous delivery of autologous adipose-derived regenerative cells (ADRCs) in the treatment of severe thermal burns using a porcine model. Burns. 2018 Jun 26. pii: S0305-4179(18)30364-4. doi: 10.1016/j.burns.2018.05.006. |
| 慢性創傷： | ・Akita S et al. Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries. Radiat Prot Dosimetry. 2012 Oct;151(4):656-60. ・Akita S et al. Noncultured autologous adipose-derived stem cells therapy for chronic radiation injury. Stem Cells Int. 2010 Dec 1;2010:532704. doi: 10.4061/2010/532704. ・Andjelkov K et al. A novel method for treatment of chronic anal fissure: adipose-derived regenerative cells – a pilot study. Colorectal Dis. 2017 Jun;19(6):570-575. doi: 10.1111/codi.13555. ・Andjelkov K et al. Posterior Fourchette Fissure Resolution After Injection of Autologous Adipose-Derived Regenerative Cells. Obstet Gynecol. 2017 Mar;129(3):497-499. doi: 10.1097/AOG.0000000000001906. ・Cervelli V et al. Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. Stem Cell Res. 2011 Mar;6(2):103-11. doi: 10.1016/j.scr.2010.11.003. ・Iddins C et al. Case Report: Industrial X-Ray Injury Treated With Non-Cultured Autologous Adipose-Derived Stromal Vascular Fraction (SVF). Health Phys. 2016 Aug;111(2):112-6. doi: 10.1097/HP.0000000000000483. ・Karaaltin M et al. Adipose Derived Regenerative Cell Therapy for Treating a Diabetic Wound: A Case Report. Wounds. 2012 Jan;24(1):e1-5. ・Marino G et al. Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. J Surg Res. 2013 Nov;185(1):36-44. doi: 10.1016/j.jss.2013.05.024. ・Yoshimoto H et al. “Efficacy of patients’ own adipose-derived regenerative cells for chronic intractable radiation injuries.” Journal of Wound Technology, 10; 22-25; 2010. ・Akita S et al. Mesenchymal stem cell therapy for cutaneous radiation syndrome. Health Phys. 2010 Jun;98(6):858-62. doi: 10.1097/HP.0b013e3181d3d52c. |
| 勃起不全： | ・Haahr M et al. Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. 2016 Jan 19;5:204-10. doi: 10.1016/j.ebiom.2016.01.024. eCollection 2016 Mar. ・Haahr M et al. Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: A 12-Month Follow-Up. The Journal of Urology, 197:4; e542; 2017. |
| 瘻孔： | ・Borowski D et al. Adipose Tissue-Derived Regenerative Cell-Enhanced Lipofilling for Treatment of Cryptoglandular Fistulae-in-Ano: The ALFA Technique. Surg Innov. 2015 Dec;22(6):593-600. doi: 10.1177/1553350615572656. ・Borowski D et al. Autologous adipose-tissue derived regenerative cells for the treatment of complex cryptoglandular fistula-in-ano: a report of three cases. BMJ Case Rep. 2012 Nov 9;2012. pii: bcr2012006988. doi: 10.1136/bcr-2012-006988. ・Foll et al. Successful closure of persistent oro-cutaneous fistulas by injection of autologous adipose-derived stem cells: a case report. GMS Ger Plast Reconstr Aesthet Surg. 2013;3:Doc05. DOI:10.3205/gpras000015,URN:urn:nbn:de:0183-gpras0000150 ・Mizushima T et al. A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula. Surg Today. 2016 Jul;46(7):835-42. doi: 10.1007/s00595-015-1246-8. ・Philandrianos C et al. First clinical case report of local microinjection of autologous fat and adipose-derived stromal vascular fraction for perianal fistula in Crohn’s disease. Stem Cell Res Ther. 2018 Jan 10;9(1):4. doi: 10.1186/s13287-017-0736-6. |
| 心疾患： | ・Henry T et al. The Athena trials: Autologous adipose-derived regenerative cells for refractory chronic myocardial ischemia with left ventricular dysfunction. Catheter Cardiovasc Interv. 2017 Feb 1;89(2):169-177. doi:10.1002/ccd.26601. ・Houtgraaf J et al. First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012 Jan 31;59(5):539-40. doi: 10.1016/j.jacc.2011.09.065. ・Perin E et al. Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial. Am Heart J. 2014 Jul;168(1):88-95.e2. doi: 10.1016/j.ahj.2014.03.022. ・Duckers H et al. The Bedside Celution system for isolation of adipose derived regenerative cells. EuroIntervention. 2006 Nov;2(3):395-8. |
| 変形性膝関節症： | ・Smyshlyaev I et al. “Safety and Effectiveness of Intraarticular Administration of Adipose-Derived Stromal Vascular Fraction for Treatment of Knee Articular Cartilage Degenerative Damage: Preliminary Results of a Clinical Trial.” Traumatology and Orthopedics of Russia, 23:3; 17-31; 2017. ・Yokota N et al. “Clinical results following intra-articular injection of adipose-derived stromal vascular fraction cells in patients with osteoarthritis of the knee.” Regenerative Therapy, 6; 108-112; 2017. |
| 肝硬変： | ・Sakai Y et al. “Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell.” Regenerative Therapy, 6; 52-64; 2017. |
| リンパ浮腫： | ・Toyserkani N et al. Treatment of Breast Cancer-Related Lymphedema with Adipose-Derived Regenerative Cells and Fat Grafts: A Feasibility and Safety Study. Stem Cells Transl Med. 2017 Aug;6(8):1666-1672. doi: 10.1002/sctm.17-0037. ・Toyserkani N et al. Cell-Assisted Lipotransfer Using Autologous Adipose-Derived Stromal Cells for Alleviation of Breast Cancer-Related Lymphedema. Stem Cells Transl Med. 2016 Jul;5(7):857-9. doi: 10.5966/sctm.2015-0357. |
| 神経腫： | ・Calcagni M et al. The novel treatment of SVF-enriched fat grafting for painful end-neuromas of superficial radial nerve. Microsurgery. 2018 Mar;38(3):264-269. doi:10.1002/micr.30122. |
| 形成再建外科： | ・Gentile P et al. Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face. J Craniofac Surg. 2014 Jan;25(1):267-72. doi: 10.1097/01.scs.0000436746.21031.ba. ・Herold et al. Supplementation of fat grafts with adipose-derived regenerative cells in reconstructive surgery. GMS Ger Plast Reconstr Aesthet Surg. 2012;2:Doc07. DOI:10.3205/gpras000009,URN:urn:nbn:de:0183-gpras0000099 ・Kakudo N et al. Adipose-derived regenerative cell (ADRCs)-enriched fat grafting: optimal cell concentration and effects on grafted fat characteristics. J Transl Med. 2013 Oct 10;11:254. doi: 10.1186/1479-5876-11-254. ・Karaaltin M et al. Treatment of “en coup de sabre” deformity with adipose-derived regenerative cell-enriched fat graft. J Craniofac Surg. 2012 Mar;23(2):e103-5. doi: 10.1097/SCS.0b013e3182418ce8. |
| 強皮症： | ・Daumas A et al. Long-term follow-up after autologous adipose-derived stromal vascular fraction injection into fingers in systemic sclerosis patients. Curr Res Transl Med. 2017 Jan – Mar;65(1):40-43. doi: 10.1016/j.retram.2016.10.006. ・Granel B et al. Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial. Ann Rheum Dis. 2015 Dec;74(12):2175-82. doi: 10.1136/annrheumdis-2014-205681. ・Guillaume-Jugnot P et al. Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up. Rheumatology (Oxford). 2016 Feb;55(2):301-6. doi: 10.1093/rheumatology/kev323. ・Khanna D et al. Adipose-Derived Cell Therapy for Hand Dysfunction in Patients with Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial. Paper presented at: 5th Systemic Sclerosis World Congress. 2018 Feb 15 – 17; Bordeaux, France. ・Magalon G et al. Regenerative Approach to Scleroderma with Fat Grafting. Clin Plast Surg. 2015 Jul;42(3):353-64, viii-ix. doi: 10.1016/j.cps.2015.03.009. Review. |
| 腹圧性尿失禁： | ・Boissier R et al. Histological and Urodynamic Effects of Autologous Stromal Vascular Fraction Extracted from Fat Tissue with Minimal Ex Vivo Manipulation in a Porcine Model of Intrinsic Sphincter Deficiency. J Urol. 2016 Sep;196(3):934-42. doi: 10.1016/j.juro.2016.04.099. ・Choi J et al. Adipose-Derived Regenerative Cell Injection Therapy for Postprostatectomy Incontinence: A Phase I Clinical Study. Yonsei Med J. 2016 Sep;57(5):1152-8. doi: 10.3349/ymj.2016.57.5.1152. ・Gotoh M et al. Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients. Int J Urol. 2014 Mar;21(3):294-300. doi: 10.1111/iju.12266. ・Gotoh M et al. Long-term durability of efficacy and safety of regenerative treatment of male stress urinary incontinence using autologous adipose-derived regenerative cells [abstract]. In: ICS 2017.;2017 Sep 12 – 15; Florence, Italy. International Continence Society; 2017. Abstract nr 489. ・Shimizu S et al. Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol. BMC Urol. 2017 Sep 25;17(1):89. doi: 10.1186/s12894-017-0282-7. ・Yamamoto T et al. Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases. Int J Urol. 2012 Jul;19(7):652-9. doi: 10.1111/j.1442-2042.2012.02999.x. |
| 声帯修復： | ・Mattei A et al. Autologous adipose-derived stromal vascular fraction and scarred vocal folds: first clinical case report. Stem Cell Res Ther. 2018 Jul 27;9(1):202. doi: 10.1186/s13287-018-0842-0. |
| その他： | ・Aronowitz J et al. Adipose stromal vascular fraction isolation: a head-to-head comparison of four commercial cell separation systems. Plast Reconstr Surg. 2013 Dec;132(6):932e-9e. doi: 10.1097/PRS.0b013e3182a80652. ・Fraser J et al. The Celution® System: Automated Processing of Adipose-Derived Regenerative Cells in a Functionally Closed System. Adv Wound Care (New Rochelle). 2014 Jan 1;3(1):38-45. ・Kesten S et al. Autologous Adipose Derived Regenerative Cells: A Platform for Therapeutic Applications. Surg Technol Int. 2016 Oct 26;29:38-44. |
